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Dr Mette Jorgensen

Consultant Paediatric Oncologist


Dr Mette Jorgensen joined Great Ormond Street Hospital (GOSH) in 2015 having completed specialty training in paediatric oncology at GOSH and University College London Hospital. Dr Jorgensen was awarded PhD in Cancer Biology and Gene Therapy from University College London (UCL) 2016.

Dr Jorgensen specialises in paediatric neuro-oncology (tumours of the brain and spine), paediatric soft-tissue sarcoma and is the clinical lead for cancer genetics (familial cancer pre-disposition syndrome). She is the UK Principal Investigator (PI) for International Society of Paediatric Oncology (SIOP) PNET5 international clinical trial for Standard risk Medulloblastoma and Chief investigator (CI) for SIOP Ependymoma international clinical trial and chairs the Neuro-oncology MDT at GOSH. She is a member of the EpSSG (European soft tissue sarcoma group) and works within an excellent team of experts of neuro-oncologist and sarcoma specialists at GOSH.

Dr Jorgensen says: “I aim to provide the best care and therapy for the child in front of me. I work with national and international experts to ensure we continue to improve our understanding of tumour biology and outcome for our patients.”

Languages Spoken:

  • English
  • Danish


  • Neuro-oncology (brain tumours)
  • Soft tissue sarcoma (Rhabdomyosarcoma, rhabdoid tumours, Ewing sarcoma, Infantile Fibrosarcoma and rare tumours including adrenocortical carcinoma)
  • Germ cell tumour (GCT)
  • Cancer predisposition (Li-Fraumeni syndrome)
  • Retinoblastoma (intra-arterial chemotherapy)
  • Neuro-oncology (brain tumours)
  • Soft tissue sarcoma (Rhabdomyosarcoma, rhabdoid tumours, Ewing sarcoma, Infantile Fibrosarcoma and rare tumours including adrenocortical carcinoma)
  • Germ cell tumour (GCT)
  • Cancer predisposition (Li-Fraumeni syndrome)
  • Retinoblastoma (intra-arterial chemotherapy)
  • MD Aarhus University Denmark 2000
  • PhD University College London (UCL) “Cancer biology and gene therapy”
  • Trained in GOSH and University College London Hospital (Sarcoma specialist service and Adolescent Oncology)
  • The biology of childhood Sarcoma and Germ Cell tumours (Collaboration with the Sanger Institute)
  • Cancer Pre-disposition syndromes (Collaboration with the Sanger Institute)
  • Surveillance in children with Li-Fraumeni Syndrome (TP53)
  • Improving outcome for children with brain tumours (NCRI CSG CNS – clinical trials)

News & Publications

Tumour-agnostic drugs in paediatric cancers. Thomas Oliver, Thomas Jackson, Olumide Ogunbiyi, Neil Sebire, Olga Slater, Mette Jorgensen and Sam Behjati; BJC Manuscript: LT-2020-9110  (accepted for publication June 2020)

UKCGG Consensus Group guidelines for the management of patients with constitutional TP53 pathogenic variants. Hanson H, Brady AF, Jorgensen M, Crawford G, et al. J Med Genet Epub ahead of print: [please include Day Month Year]. doi:10.1136/jmedgenet-2020-106876

Embryonal precursors of Wilms tumor. Tim H. H. Coorens Taryn D. Treger  Reem Al-Saadi, Luiza Moore, Maxine G. B. Tran, Thomas J. Mitchell, Suzanne Tugnait, … Mette Jorgensen, Neil Sebire, Jarno Drost, Kourosh Saeb-Parsy, Michael R. Stratton, Karin Straathof, Kathy Pritchard-Jones, Sam Behjati. Science 366, 1247–1251 (2019) 6 December 2019

Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants. Jenny Wegert, Christian Vokuhl, Grace Collord, Martin Del Castillo Velasco-Herrera, Sarah J. Farndon, Charlotte Guzzo, Mette Jorgensen, John Anderson, Olga Slater,.... Manfred Gessler, Sam Behjati. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-04650-6

Mutational signatures of ionizing radiation in second malignancies. Behjati, S., Gundem, G., Wedge, D. C., Roberts, N. D., Tarpey, P. S., Cooke, S. L., Jorgensen, M., et al. (2016). Nature Communications, 7, 12605. doi:10.1038/ncomms12605

EGFR inhibitors Identified as a Potential Treatment for Chordoma in a Focused Compound Screen. Scheipl, S., Barnard, M., Cottone, L., Jorgensen, M., Drewry, D. H., Zuercher, W. J., et al. 2016 The Journal of Pathology. doi:10.1002/path.4729

Chordoma Specimens by Targeted Next-Generation Cancer Panel Sequencing. Fischer, C., Scheipl, S., Zopf, A., Niklas, N., Deutsch, A., Jorgensen, M., et al. (2015). Mutation Analysis of Nine... Journal of Cancer, 6(10), 984–989. doi:10.7150/jca.11371

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