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达伦·哈格雷夫(Darren Hargrave) 医生

儿科肿瘤学顾问专家

概述

达伦·哈格雷夫教授自2011年加入大奥蒙德街儿童医院(GOSH),之前就职于伦敦皇家马斯登癌症中心。他于2017年被任命为GOSH儿童慈善组织小儿神经肿瘤科的临床教授。

哈格雷夫教授专门研究儿童神经肿瘤(大脑和脊椎肿瘤),以及为儿童和青少年开发新的抗癌药物。他曾在英国和加拿大(多伦多病童医院)接受过培训。他是该领域的国际领袖,同时也是欧洲的儿童脑肿瘤组的主席(当选人),同时也是几个国家和国际临床和研究委员会的成员。从“First-in-child” 计划到国际随机研究,他是几项已完成的、正在进行的和计划中的儿科癌症临床试验的首席研究员。 

“在我的肿瘤治疗生涯早期,我在于患脑肿瘤的患儿一起工作时得到了激励和启发。我想要通过了解肿瘤的生物学特性,开发更好的治疗方法并改善结果。”

相关资质

  • 神经肿瘤(脑肿瘤)
  • 儿童癌症的实验性疗法
  • 多发性神经纤维瘤相关肿瘤
  • ​​​​​英国利兹大学医学学士
  • 伦敦大学医学博士
  • 英国皇家内科医师学会会员 
  • 英国皇家儿科与儿童健康医学院研究员
  • 在英国大奥蒙德街儿童医院和加拿大多伦多病童医院接受过培训
  • 癌症基因组计划、桑格中心和癌症研究所的研究学位
  • 儿童脑肿瘤生物学
  • 创新成像技术在儿童癌症中的使用
  • 针对儿童和青少年肿瘤的靶向治疗的药物开发

新闻和论文发表

Stone, T.J., Keeley, A., Virasami, A., Harkness, W., Tisdall, M., Izquierdo Delgado, E., Gutteridge, A., Brooks, T., Kristiansen, M., Chalker, J., Wilkhu, L., Mifsud, W., Apps, J., Thom, M., Hubank, M., Forshew, T., Cross, J.H., Hargrave, D., Ham, J., Jacques, T.S. 2017. Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours. Acta Neuropathol. 

Jones, D.T.W., Kieran, M.W., Bouffet, E., Alexandrescu, S., Bandopadhayay, P., Bornhorst, M., Ellison, D., Fangusaro, J., Fisher, M.I., Foreman, N., Fouladi, M., Hargrave, D., Hawkins, C., Jabado, N., Massimino, M., Mueller, S., Perilongo, G., Schouten-van Meeteren, A.Y.N., Tabori, U., Warren, K., Waanders, A.J., Walker, D., Weiss, W., Witt, O., Wright, K., Zhu, Y., Bowers, D.C., Pfister, S.M., Packer, R.J. 2017. Pediatric Low-Grade Gliomas: Next Biologically Driven Steps. Neuro Oncol.

Kieran, M.W., Chisholm, J., Casanova, M., Brandes, A.A., Aerts, I., Bouffet, E., Bailey, S., Leary, S., MacDonald, T.J., Mechinaud, F., Cohen, K.J., Riccardi, R., Mason, W., Hargrave, D., Kalambakas, S., Deshpande, P., Tai, F., Hurh, E., Geoerger, B. 2017. Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma. Neuro Oncol. 

Byrne, S., Connor, S., Lascelles, K., Siddiqui, A., Hargrave, D., Ferner, R.E. 2017. Clinical presentation and prognostic indicators in 100 adults and children with neurofibromatosis 1 associated non-optic pathway brain gliomas. J Neurooncol.

Vormoor, B., Veal, G.J., Griffin, M.J., Boddy, A.V., Irving, J., Minto, L., Case, M., Banerji, U., Swales, K.E., Tall, J.R., Moore, A.S., Toguchi, M., Acton, G., Dyer, K., Schwab, C., Harrison, C.J., Grainger, J.D., Lancaster, D., Kearns, P., Hargrave, D., Vormoor, J. 2017. A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia. Pediatr Blood Cancer. 64(6).

Bluebond-Langner, M., Hargrave, D., Henderson, E.M., Langner, R. 2017. 'I have to live with the decisions I make': laying a foundation for decision making for children with life-limiting conditions and life-threatening illnesses. Arch Dis Child. 102(5) pp. 468-471.

Kinsler, V.A., O'Hare, P., Bulstrode, N., Calonje, J.E., Chong, W.K., Hargrave, D., Jacques, T., Lomas, D., Sebire, N.J., Slater, O. 2017. Melanoma in congenital melanocytic naevi. Br J Dermatol. 176(5) pp. 1131-1143.

Kinsler, V.A., O'Hare, P., Jacques, T., Hargrave, D., Slater, O. 2017. MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children. Br J Cancer. 116(8) pp. 990-993.

Veldhuijzen van Zanten, S.E., Baugh, J., Chaney, B., De Jongh, D., Sanchez Aliaga, E., Barkhof, F., Noltes, J., De Wolf, R., Van Dijk, J., Cannarozzo, A., Damen-Korbijn, C.M., Lieverst, J.A., Colditz, N., Hoffmann, M., Warmuth-Metz, M., Bison, B., Jones, D.T., Sturm, D., Gielen, G.H., Jones, C., Hulleman, E., Calmon, R., Castel, D., Varlet, P., Giraud, G., Slavc, I., Van Gool, S., Jacobs, S., Jadrijevic-Cvrlje, F., Sumerauer, D., Nysom, K., Pentikainen, V., Kivivuori, S.M., Leblond, P., Entz-Werle, N., von Bueren, A.O., Kattamis, A., Hargrave, D.R., et al. Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. J Neurooncol. 132(2) pp. 255-266.

Baugh, J., Bartels, U., Leach, J., Jones, B., Chaney, B., Warren, K.E., Kirkendall, J., Doughman, R., Hawkins, C., Miles, L., Fuller, C., Hassall, T., Bouffet, E., Lane, A., Hargrave, D., Grill, J., Hoffman, L.M., Jones, C., Towbin, A., Savage, S.A., Monje, M., Li, X.N., Ziegler, D.S., Veldhuijzen van Zanten, S., Kramm, C.M., van Vuurden, D.G., Fouladi, M. 2017. The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease. J Neurooncol. 132(2) pp. 323-331. 

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