Dr Brugha read medicine at Oxford and completed his higher specialist training in Paediatric Respiratory Medicine on the London rotation (Royal Brompton Hospital and Great Ormond Street Hospital). During postgraduate training he obtained his PhD (University of London, 2015) on the impact of air pollution on children’s respiratory health. He was subsequently appointed as an NIHR Academic Clinical Lecturer at Imperial College, where he worked in the cystic fibrosis research group. He was appointed as an NHS Consultant in 2018 and has worked at Great Ormond Street Hospital, in the respiratory and lung transplant team, since 2020.
Dr Brugha is active in research and is a co-lead of the London Cystic Fibrosis Collaboration, as well as centre lead at Great Ormond Street for CF trials. He is an Honorary Associate Professor at the Great Ormond Street UCL Institute of Child Health. He has publications in major journals including Science, Lancet Respiratory Medicine, and Thorax.
He has presented at international conferences including the American Thoracic Society, European Respiratory Society, European Cystic Fibrosis Society and British Thoracic Society meetings, as well as an award lecture at the British Science Festival, interviews on BBC News, BBC Radio 4 and ITV News about his research.
- Environmentally associated lung disease including wheezing disorders and infection.
- Genetically associated disorders including cystic fibrosis, interstitial lung disease.
- Complex paediatrics including children with cardio-respiratory and immune disorders.
- Respiratory physiology including exercise testing
- Infection, immunity and inflammation
- End stage respiratory disorders including lung transplantation
BM BCh, University of Oxford, 2005
Member of the Royal College of Paediatrics and Child Health, 2009
PhD, University of London (QMUL), 2015
British Paediatric Respiratory Society
British Thoracic Society
European Respiratory Society
Immune function; particularly post lung transplantation
Cystic fibrosis; randomised controlled trials and electronic datasets
Brugha R, Spencer H. Mycobacterium abscessus in cystic fibrosis. Science 2021 Apr 30;372(6541):465-466. doi: 10.1126/science.abi5695. PMID: 33926941
Rossa Brugha, Helen Spencer. Lung Transplantation in Children, Reference Module in Biomedical Sciences, Elsevier, 2021. ISBN 9780128012383, https://doi.org/10.1016/B978-0-08-102723-3.00142-6.
Brugha R, Aurora P. Lung involvement in the immunocompromised host. ERS Handbook of Paediatric Respiratory Medicine, 2nd edition. Editors: Fabio Midulla, Ernst Eber. European Respiratory Society, 2021 ISBN: 1849841314, 9781849841313
Brugha R, Nwokoro C, Grigg J. Upper Respiratory Tract Infections. Chapter in ERS Handbook of Paediatric Respiratory Medicine, 2nd edition. Editors: Fabio Midulla, Ernst Eber. European Respiratory Society, 2021 ISBN: 1849841314, 9781849841313
Whitehouse AL, Mushtaq N, Miyashita L, Barratt B, Khan A, Kalsi H, Koh L, Padovan MG, Brugha R, Balkwill FR, Stagg AJ, Grigg J. Airway dendritic cell maturation in children exposed to air pollution. PLoS One. 2020 May 5;15(5):e0232040. doi: 10.1371/journal.pone.0232040. PMID: 32369498
Brugha R, Wright M, Nolan S, Bridges N, Carr SB. Quantifying fluctuation in glucose levels to identify early changes in glucose homeostasis in cystic fibrosis. J Cyst Fibros. 2018 Jan 9. doi: 10.1016/j.jcf.2017.12.004. PMID: 2932972
Brugha R, Lowe R, Henderson AJ, Holloway JW, Rakyan V, Wozniak E, Mahmud N, Seymour K, Grigg J, Shaheen SO. DNA methylation profiles between airway epithelium and proxy tissues in children. Acta Paediatr. 2017 Dec;106(12):2011-2016. PMID: 28833606
Brugha R, Mushtaq N, McCarthy N, Stagg AJ, Grigg J. Respiratory tract dendritic cells in paediatric asthma. Clin Exp Allergy 2015 Mar;45(3):624-31 PMID: 25411998
Nwokoro C, Pandya H, Turner S, Eldridge S, Griffiths CJ, Vulliamy T, Price D, Sanak M, Holloway JW, Brugha R, Koh L, Dickson I, Rutterford C, Grigg J. Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial. Lancet Respir Med. 2014 Oct;2(10):796-803.
Brugha RE, Mushtaq M, Round T, Gadhvi DH, Dundas I, Gaillard E, Koh L, Fleming LJ, Lewis DJ, Sanak M, Wood HE, Barratt D, Mudway IS, Kelly FJ, Griffiths CJ, Grigg J. Carbon in airway macrophages from children with asthma. Thorax 2014;69:654-659 PMID: 24567296
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