Kanchan Rao 医生

骨髓移植专科主任及骨髓移植专家顾问医师

概述

Kanchan Rao 医生自1999年起在大奥蒙德街儿童医院(GOSH )骨髓移植团队(BMT)工作,并担任专科主任职位, 至今已在该团队服务超20余年。她参与并开发了一系列的治疗包括:非亲缘供体移植,非自体干细胞移植,脐带血移植以及针对高风险淋巴恶性肿瘤的最新CAR-T细胞疗法。Kanchan Rao 医生是英国及爱尔兰地区小儿骨髓移植组织的主席,并主持每个月国内及国际针对复杂疾病案例的会议讨论。

Kanchan Rao 医生是噬血细胞性淋巴组织细胞增多症(HLH)多学科国家小组的成员,该小组定期讨论针对HLH疾病复杂病例的管理。Rao医生对HLH非常感兴趣,该疾病也是她的研究领域之一。她也对骨髓移植后的病毒并发症领域很感兴趣,尤其是腺病毒。她在同行评审的期刊上发表了60多篇论文。

使用语言:

  • English
  • Hindi
  • Tamil

相关资质

  • 噬血细胞性淋巴组织细胞增多症(HLH
  • 针对非恶性病情的骨髓移植
  • 幼年型粒单核细胞白血

Rao医生对HLH非常感兴趣,该疾病也是她的研究领域之一。她也对骨髓移植后的病毒并发症领域很感兴趣,尤其是腺病毒

  • MBBS, 医学博士MD
  • 英国/爱尔兰儿科BMT小组主席
  • 印度国家医学院成员(MNAMS)
  • 英国皇家儿科医学院成员(MRCPCH)
  • 欧洲先天错误工作组成员 (the Inborn Errors Working Party,IEWP)
  • 组织细胞学会会员
  •  
  • 骨髓移植后腺病毒并发症的管理
  • CAR-T细胞疗法治疗复发/难治性B细胞白血病

新闻和论文发表

Lankester AC, Neven B, Mahlaoui N, von Asmuth EG, Courteille V, Alligon M, Albert MH, Serra IB, Bader P, Balashov D, Beier R, Bertrand Y, Blanche S, Bordon V, Bredius RG, Cant A, Cavazzana M, Diaz-de-Heredia C, Dogu F, Ehlert K, Entz-Werle N, Fasth A, Ferrua F, Ferster A, Formankova R, Friedrich W, Gonzalez-Vicent M, Gozdzik J, Güngör T, Hoenig M, Ikinciogullari A, Kalwak K, Kansoy S, Kupesiz A, Lanfranchi A, Lindemans CA, Meisel R, Michel G, Miranda NA, Moraleda J, Moshous D, Pichler H, Rao K, Sedlacek P, Slatter M, Soncini E, Speckmann C, Sundin M, Toren A, Vettenranta K, Worth A, Yeşilipek MA, Zecca M, Porta F, Schulz A, Veys P, Fischer A, Gennery AR. Hematopoietic cell transplantation in severe combined immunodeficiency: the SCETIDE 2006-2014 European cohort

J Allergy and Clin Imm. 2021 Oct 27;S0091-6749(21)01629-8. doi: 10.1016/j.jaci.2021.10.017. Online ahead of print

Laberko A, Deordieva E, Krivan G, Goda V, Bhar S, Kawahara Y, Rao K, Worth A, McDermott DH, Balashov D, Maschan A, Shcherbina A. Multicenter Experience of Hematopoietic Stem Cell Transplantation in WHIM Syndrome. J Clin Immunol. 2021 Oct 26.  doi: 10.1007/s10875-021-01155-8. Online ahead of print.

Escaron C, Ralph E, Bibi S, Visser J, Aricò M, Rao K, Veys P, Gilmour K. Diagnosis of HLH: two siblings, two distinct genetic causes. Clin Exp Immunol. 2021 Nov 30. Online ahead of print

Kreins AY, Velasco HF, Cheong KN, Rao K, Veys P, Worth A, Gaspar HB, Booth C.Kreins AY, et al. Long-Term Immune Recovery After Hematopoietic Stem Cell Transplantation for ADA Deficiency: a Single-Center Experience  J Clin Immunol. 2021 Oct 16. doi: 10.1007/s10875-021-01145-w. Online ahead of print.

Cordoba S, Onuoha S, Thomas S, Pignataro DS, Hough R, Ghorashian S, Vora A, Bonney D, Veys P, Rao K, Lucchini G, Chiesa R, Chu J, Clark L, Fung MM, Smith K, Peticone C, Al-Hajj M, Baldan V, Ferrari M, Srivastava S, Jha R, Arce Vargas F, Duffy K, Day W, Virgo P, Wheeler L, Hancock J, Farzaneh F, Domning S, Zhang Y, Khokhar NZ, Peddareddigari VGR, Wynn R, Pule M, Amrolia PJ.Cordoba S, et al. CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial Nat Med. 2021 Oct;27(10):1797-1805. doi: 10.1038/s41591-021-01497-1. Epub 2021 Oct 12.

Arnold DE, Nofal R, Wakefield C, Lehmberg K, Wustrau K, Albert MH, Morris EC, Heimall JR, Bunin NJ, Kumar A, Jordan MB, Cole T, Choo S, Brettig T, Speckmann C, Ehl S, Salamonowicz M, Wahlstrom J, Rao K, Booth C, Worth A, Marsh RA.Arnold DE, et al.  Reduced-Intensity/Reduced-Toxicity Conditioning Approaches Are Tolerated in XIAP Deficiency but Patients Fare Poorly with Acute GVHD. J Clin Immunol. 2021 Sep 29:1-10. doi: 10.1007/s10875-021-01103-6. Online ahead of print.

Ottaviano G, Achini-Gutzwiller F, Kalwak K, Lanino E, Faraci M, Rao K, Chiesa R, Amrolia P, Bonanomi S, Rovelli A, Veys P, Lankester A, Balduzzi A, Lucchini G.Impact of in Vivo Lymphodepletion on Outcome in Children with Nonmalignant Disorders Receiving Peripheral Blood Stem Cell Transplantation. Transplant Cell Ther. 2021 Aug 24:S2666-6367(21)01165-9. doi: 10.1016/j.jtct.2021.08.015. Online ahead of print.

Using Whole Genome Sequences to Investigate Adenovirus Outbreaks in a Hematopoietic Stem Cell Transplant Unit. Myers CE, Houldcroft CJ, Roy S, Margetts BK, Best T, Venturini C, Guerra-Assunção JA, Williams CA, Williams R, Dunn H, Hartley JC, Rao K, Rolfe KJ, Breuer J. Front Microbiol. 2021 Jul 2;12:667790

Dimitrova D, Nademi Z, Maccari ME, Ehl S, Uzel G, Tomoda T, Okano T, Imai K, Carpenter B, Ip W, Rao K, Worth AJJ, Laberko A, Mukhina A, Néven B, Moshous D, Speckmann C, Warnatz K, Wehr C, Abolhassani H, Aghamohammadi A, Bleesing JJ, Dara J, Dvorak CC, Ghosh S, Kang HJ, Markelj G, Modi A, Bayer DK, Notarangelo LD, Schulz A, Garcia-Prat M, Soler-Palacín P, Karakükcü M, Yilmaz E, Gambineri E, Menconi M, Masmas TN, Holm M, Bonfim C, Prando C, Hughes S, Jolles S, Morris EC, Kapoor N, Koltan S, Paneesha S, Steward C, Wynn R, Duffner U, Gennery AR, Lankester AC, Slatter M, Kanakry JA. International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome. JACI. 2021 May 24

Lum SH, Elfeky R, Achini FR, Margarit-Soler A, Cinicola B, Perez-Heras I, Nademi Z, Flood T, Cheetham T, Worth A, Qasim W, Amin R, Rao K, Chiesa R, Bredius RGM, Amrolia P, Abinun M, Hambleton S, Veys P, Gennery AR, Lankester A, Slatter M. Outcome of non-haematological autoimmunity after haematopoietic stem cell transplantation in children. J Clin Immunol. 2021 Jan;41(1):171-184

Silva JMF, Jones A, Sibson K, Bibi S, Jeggo P, Woodbine L, Ahsan G, Gilmour KC, Rao K, Chiesa R, Lucchini G, Veys P, Worth A, Amrolia PJ. Haematopoietic stem cell transplantation for DNA Ligase 1 deficiency. J Clin Immunol. 2021 Jan;41(1):238-242

Benjamin R, Graham C, Yallop D, Jozwik A, Mirci-Danicar OC, Lucchini G, Pinner D, Jain N, Kantarjian H, Boissel N, Maus MV, Frigault MJ, Baruchel A, Mohty M, Gianella-Borradori A, Binlich F, Balandraud S, Vitry F, Thomas E, Philippe A, Fouliard S, Dupouy S, Marchiq I, Almena-Carrasco M, Ferry N, Arnould S, Konto C, Veys P, Qasim W; K Rao as part of UCART19 group. Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies. Lancet. 2020 Dec 12;396(10266):1885-1894

Elfeky R, Lucchini G, Lum SH, Ottaviano G, Builes N, Nademi Z, Battersby A, Flood T, Owens S, Cant AJ, Young H, Greener S, Walsh P, Kavanagh D, Annavarapu S, Rao K, Amrolia P, Chiesa R, Worth A, Booth C, Skinner R, Doncheva B, Standing J, Gennery AR, Qasim W, Slatter M, Veys P. New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT. Blood Adv.2020 Jun 9;4(11):2418-2429

Matthias Felber  1 ,Colin G Steward  2 Karim Kentouche  3 Anders Fasth  4 Robert F Wynn  5 Ulrike Zeilhofer  1 Veronika Haunerdinger  1 Benjamin Volkmer  1 Seraina Prader  1 Bernd Gruhn  3 Stephan Ehl  6 Kai Lehmberg  7 Daniel Müller  8 Andrew R Gennery  9 Michael H Albert  10 Fabian Hauck  10 Kanchan Rao  11 Paul Veys  11 Moustapha Hassan  12 Arjan C Lankester  13 Jana Pachlopnik Schmid  1 Mathias M Hauri-Hohl  1 Tayfun Güngör 1. Targeted busulfan-based reduced-intensity conditioning and HLA-matched HSCT cure hemophagocytic lymphohistiocytosis. Blood Adv 2020. May 12; 4(9):1998-2010

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