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Dr Michael Quail

Consultant Cardiologist

Overview

Dr Michael Quail is qualified in medicine, graduating from the University of Edinburgh in 2006. He was awarded the Murdoch-Brown medal in clinical medicine. He also obtained a 1st class degree in Immunology and was awarded the class medal in Immunology.

In 2008, Dr Quail was appointed as the UK’s first academic clinical fellow in paediatric cardiology. During this time, he completed paediatric training in the North London rotation, obtained membership of the royal college of paediatrics and child health (MRCPCH), and was awarded an MSc in Advanced Paediatrics with Distinction from UCL.

In 2011, Dr Quail was awarded a fellowship by the British Heart Foundation to undertake a PhD in cardiovascular imaging and physiology at UCL. This work resulted in a number of publications, and he also won the Melvin-Judkins young investigator award by the American heart association for work on pulmonary hypertension.

In 2014, he ranked first in national recruitment for paediatric cardiology training. Dr Quail's training took place at the Royal Brompton Hospital, Great Ormond Street Hospital and St Bartholomew’s Hospital (adult congenital cardiology).

Dr Quail completed his training in paediatric cardiology with subspeciality training in cardiac MRI and adult congenital heart disease in 2019. He came first in the European association of cardiovascular imaging examination in congenital CMR in 2019 and has level 3 (highest) accreditation in congenital and paediatric CMR.

At Great Ormond Street Hospital he is a paediatric cardiologist performing cardiac MRI for paediatric and adult patients. The cardiac imaging department is one of the largest in Europe and provides the full range of cardiovascular imaging of adults and children,

Dr Quail also works as an adult congenital cardiologist at St Bartholomew’s Hospital, seeing grown up patients with congenital heart disease in his weekly clinic. He is a fellow of the royal college of paediatrics and child health (FRCPCH).

Credentials

  • Single Ventricle Congenital Heart Disease
  • Pulmonary Hypertension
  • Coarctation of the Aorta

2021 FRCPCH Royal College of Paediatrics & Child Health

2019 Level 3 Accredited in Congenital Cardiac Magnetic Resonance imaging, EACVI

2016 PhD – Cardiovascular Medicine, University College London, UK

2014 Fellowship of Higher Education Academy, Higher Education Academy, UK

2011 MSc, Advanced Paediatrics, Distinction, University College London, UK

2009 MRCPCH, Royal College of Paediatrics & Child Health

2006 MB ChB (Hons), University of Edinburgh, UK

2003 BSc (Hons), Immunology, 1st Class, University of Edinburgh, UK

Dr Michael Quail's doctoral and postdoctoral research has been focused on the development of non-invasive, pulmonary, systemic and myocardial biomarkers based on mathematical models of the cardiovascular system.

During his PhD, he implemented a technique called wave intensity analysis, applied non-invasively using CMR to the pulmonary circulation to investigate pathological waves arising in pulmonary hypertension. It was demonstrated that abnormal waves could be used to differentiate health from disease, and importantly identify patients with proximal clot due to chronic thromboembolic disease from patients with distal forms of pulmonary hypertension. Dr Quail was awarded the Melvin Judkins Young Investigator award by the American Heart Association in 2014 for this work.

In a further study Dr Quail developed and validated a methodology for deriving central aortic systolic blood non-invasively from CMR data using models of the pressure-area relationship. The aim of this experiment was to facilitate the collection central pressure data simultaneously with flow and function data for a comprehensive non-invasive hemodynamic study. Finally, both of these techniques were applied to a cohort of 50 patients with repaired coarctation of the aorta. This study demonstrated that following repair of coarctation; elevated central blood pressure arises due to a combination of increased vascular stiffness and abnormal wave reflections. These effects produce increased ventricular load and increased LV mass. He presented this work as a finalist for the Cardiovascular Disease in the Young, Early Career Investigator Award by the American Heart Association in November 2015.

In 2016 he was awarded a BHF-Fulbright scholarship. His award allowed him to spend a year at the University of Yale working on multi-modality imaging.

News & Publications

1. Quail MA, Chan I, Sarna S, Hughes M, Muthurangu V. An Estimate of Central Venous Pressure Is Associated with Early Fontan Failure Following Total Cavopulmonary Connection. Journal of Thoracic and Cardiovascular Surgery June 2020 (In press, 10.1016/j.jtcvs.2020.06.025)

2. Steeden JA, Quail MA, Gotschy A, Mortensen KH, Hauptmann A, Arridge S, Jones R, Muthurangu V. Rapid Whole-Heart CMR with Single Volume Super-resolution. Journal of Cardiovascular Magnetic 2020, 22; DOI 10.1186/s12968-020-00651-x

3. Quail MA, Segers P, Steeden JA, Muthurangu V. The Aorta After Coarctation Repair – Effects of Calibre and Curvature on Arterial Haemodynamics. Journal of Cardiovascular Magnetic Resonance 2019, 21;DOI:10.1186/s12968-019-0534-7.

4. Quail MA, Grunseich K, Baldassarre LA, Mojiban H, Marieb M, Cornfeld D, Sinusas AJ, Peters DC. Prognostic and Functional implications of Left Atrial Late Gadolinium Enhancement. Journal of Cardiovascular Magnetic Resonance 2019, 21; DOI:10.1186/s12968-018-0514-3.

5. Quail MA & Taylor AM. Congenital Heart Disease: General Principles and Imaging. Chapter 13, Section 2: The Chest and Cardiovascular System. In: Grainger and Allison’s Diagnostic Radiology 7th Edition. Elsevier, 2020.

6. Quail MA, Sinusas AJ. PET-CMR in Heart Failure - Synergistic or Redundant Imaging? Heart Failure Reviews. 2017 doi: 10.1007/s10741-017-9607-6 (Review)

7. Quail MA*, Cauldwell M*, Smith G, Heng EE, Ghonim S, Uebing A, Swan L, Li W, Patel R, Pennell DJ, Steer PJ, Johnson MR, Gatzoulis M, Babu-Narayan S. Effect of pregnancy on ventricular and aortic dimensions in repaired tetralogy of Fallot. J Am Heart Assoc 2017;6:e005420. DOI: 10.1161/JAHA.116.005420 *Joint 1st Authors

8. Quail MA, Short R, Steeden JA, Pandya B, Khushnood A, Taylor AM, Segers P, Muthurangu V. Abnormal Wave Reflections and LV Hypertrophy Late After Coarctation of the Aorta Repair. Hypertension. 2017 Mar;69(3):501-509 doi: 10.1161/hypertensionaha.116.08763

9. Quail MA, Knight DS, Steeden JA, Moledina S, Taylor AM, Segers P, Coghlan JG, Muthurangu V. Non-Invasive Pulmonary Artery Wave Intensity Analysis in Pulmonary Hypertension. Am J Physiol Heart Circ Physiol. 2015; 308 (12): H1603-H1611 10. Quail MA, Steeden JA, Knight D, Segers P, Taylor AM, Muthurangu V. Development and validation of a novel method to derive central aortic systolic pressure from the magnetic resonance aortic distension curve. J Magn Reson Imaging 2014; 40: 1064–1070

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