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Dr Thomas Jacques

Consultant Neuropathologist. Reader

Overview

Dr Tom Jacques runs a research group at the University College London (UCL) Great Ormond Street Institute of Child Health focussing on brain tumours and paediatric epilepsy and provides the diagnostic neuropathology service for Great Ormond Street Hospital (GOSH).  

He has held a Clinician Scientist Award for the past six years and has recently been awarded a nationally competitive HEFCE Clinical Senior Lectureship.  

Dr Jacques’ research focuses on the role of stem cells in the development of paediatric brain disease. Specifically, he has shown that the major types of brain tumour can arise from stem cells and that the type of tumour is determined by the initiating genetic mutation (Jacques et al. EMBO J 2010;29:222-35). Tom has also isolated a pathological stem cell from a malformation of cortical development in children with severe epilepsy (Yasin et al. Acta Neuropathologica 2010; 120:85-96). 

Credentials

• Neuropathology

• Paediatric neuropathology 
• Brain tumour diagnosis 
• Pathology of epilepsy 
• Autopsy pathology in children

Training: 
 
• BA (Hons) from the University of Cambridge 
• MA from the University of Cambridge 
• PhD Doctor of Philosophy – Neuroscience from the University of Cambridge  
• MB BChir Medicine/surgery from the University of Cambridge  
• MRCP  
• MRCPath 
• FRCPath 
 
Membership:  
 
• Royal College of Physicians (London) 
• Royal College of Pathologists 
• British Neuropathological Society 
• Pathological Society of Great Britain and Ireland 
• American Association of Neuropathologists 
• British Myology Society 
• Children’s Cancer and Leukaemia Group 

Dr Jacques leads a research group that looks into understanding the cellular mechanisms that underlie childhood brain diseases with a focus on brain tumours and diseases causing epilepsy. They use this information to improve diagnosis for children with these disorders.

Current areas of focus include understanding gene networks underlying epilepsy-associated tumours, providing better diagnosis for high risk brain tumours and investigating focal cortical dysplasia, a major cause of severe childhood epilepsy. 

News & Publications

Jacques, T.S. and Michalski, A.J., in press. Embryonal brain tumours in children In. M. Pignatelli, P. Gallagher Ed. In press. Recent Advances in Histopathology. London: JP Medical Publishers.  

Smith, C., and Jacques, T.S., 2015. Acquired disorders of the nervous system In. T.Y Khong, R.G.G. Malcolmson Ed. 2015. Keeling’s Fetal and Neonatal Pathology 5th edition. New York: Springer. 

Jacques, T.S. and Harding, B., 2015. Metabolic and neurodegenerative diseases of childhood In S. Love., Budka, H., J. W. Ironside. Ed. 2015. Greenfield’s Neuropathology. 9th edition, USA:CRC Press.  

Stone, T.J., Jacques, T.S., 2015. Medulloblastoma: selecting children for reduced treatment. Neuropathology and Applied Neurobiology. 41(2) pp. 106-108. 
 
Hill, R.M., Kuijper, S., Lindsey, J.C., et al 2015. Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease. Cancer Cell. 27(1) pp. 72-84. 
 
Sebire, N.J., Ashworth, M., Malone, M., Jacques, T.S., 2010. Diagnostic Pediatric Surgical Pathology. London: Churchill Livingstone Elsevier. 
 
Yasin, S.A., Ali, A.M., Tata, M., Picker, S.R., Anderson, G.W., Latimer-Bowman, E., Nicholson, S.L., Harkness, W., Cross, J.H., Paine, S.M.L., Jacques, T.S., 2013. mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: Evidence from focal cortical dysplasia and tuberous sclerosis. Acta Neuropathologica. 126 pp. 207-18. 
 
Yasin, S.A., Latak, K., Becherini, F., Ganapathi, A., Miller, K., Campos, O., Picker, S.R., Bier, N., Smith, M., Thom, M., Anderson, G., Cross, J.H., Harkness, W., Harding, B., Jacques, T.S., 2010. Balloon cells in human cortical dysplasia and tuberous sclerosis: Isolation of a pathological progenitor-like cell. Acta Neuropathologica. 120 pp. 85-96. 
 
Jacques, T.S., Swales, A., Brzozowski, M.J., Henriquez, N.V., Linehan, J.M., Mirzadeh, Z., O’Malley, C., Naumann, H., Alvarez-Buylla, A., Brandner, S., 2010. Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes. EMBO Journal. 29 pp. 222-35. 

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